"Case Closed: The Mirapolis Investigation" (also known as Case Closed: One Truth Prevails) is based on the ongoing manga and anime Detective Conan, released internationally as Case Closed. Players use the Wii Remote to find clues and solve the cases.

The game follows Conan, Mouri, Ran, and The Junior Detective League as they are invited to the opening of a new hotel called The Mirapolis. But on the first day, someone is murdered. Now Conan must find out who did it.