Caliber .50 is a 1989 scrolling shooter arcade game developed by SETA Corporation.

Players control a United States Air Force pilot who was taken as a prisoner of war in Vietnam in 1972. The pilot must escape the prison compound by battling enemy soldiers with guns and grenades. Various power-ups are available that give the player use of various other weapons including a machine gun and flamethrower. Enemy vehicles such as a plane can also be commandeered.