BioShock 2 is the second game of the BioShock series and the sequel to BioShock. It continues the grand storyline of the underwater metropolis Rapture. BioShock 2 capitalizes and improves upon the high-quality effects, unique gameplay elements, and immersive atmosphere that defined the first game. It explores more brutal gameplay than its predecessor, with new enemies, weapons, Plasmids, and Gene Tonics.

Set eight years after the events of the first game, BioShock 2 follows Subject Delta, a prototype Big Daddy sent on a quest to reunite with the Little Sister he was previously bonded to, Eleanor, across a changed and even more dangerous Rapture.