It builds upon the story and mechanics of Marie & Elie: Two People's Atelier, and introduces a brand new protagonist named Anis Ryftchen in addition to the returning two.

The main goal of the game is to create new items and recipes for several books over five years. The events and outcome of the game will differ depending on the content created for the books.

The two alchemists Marlone (most commonly refered to as "Marie") and Elfir "Elie" Traum run a workshop together on the Artisan's Way in the city of Salburg. It's not a big business, but their reputation is steadily going up. One day, their past teacher Ingrid requests them to write books for the new library that is being built. The library will be finished in 5 years, so they are requested to write at least one book every year during that time.

During the years, Marie and Elie are introduced to Anis Ryftchen, a young alchemist studying to become a teacher. While Anis initially seems cheerful, it's soon revealed that she is overworking herself. Anis is struggling to keep up with both her work at the academy and her vision to write books for her school back in the Southern Country. Marie and Elie offers to help her, but this is ultimately up to the player to choose.